Tyrosine hydroxylase polymorphism in familial and sporadic Parkinson's disease
Identifieur interne : 005A74 ( Main/Exploration ); précédent : 005A73; suivant : 005A75Tyrosine hydroxylase polymorphism in familial and sporadic Parkinson's disease
Auteurs : V. Planté-Bordeneuve [Royaume-Uni] ; M. B. Davis [Royaume-Uni] ; D. M. Maraganore [Royaume-Uni] ; C. D. Marsden [Royaume-Uni] ; Harding [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1994.
English descriptors
- KwdEn :
- Alleles, Chromosome Mapping, DNA (genetics), Gene Frequency (genetics), Genetic Linkage (genetics), Heterozygote Detection, Humans, Linkage analysis, Parkinson Disease (diagnosis), Parkinson Disease (enzymology), Parkinson Disease (genetics), Parkinson's disease, Polymerase Chain Reaction, Polymorphism, Genetic, Tyrosine 3-Monooxygenase (blood), Tyrosine 3-Monooxygenase (genetics), Tyrosine hydroxylase.
- MESH :
- chemical , blood : Tyrosine 3-Monooxygenase.
- chemical , genetics : DNA, Tyrosine 3-Monooxygenase.
- diagnosis : Parkinson Disease.
- enzymology : Parkinson Disease.
- genetics : Gene Frequency, Genetic Linkage, Parkinson Disease.
- Alleles, Chromosome Mapping, Heterozygote Detection, Humans, Polymerase Chain Reaction, Polymorphism, Genetic.
Abstract
Tyrosine hydroxylase (TH) is a theoretical candidate gene determining susceptibility to Parkinson's disease (PD), and an association between one allele of a polymorphism at the TH locus and sporadic PD has been reported. We investigated TH polymorphism in 44 patients with sporadic PD, 48 patients with familial PD and 89 of their unaffected relatives, and 50 control subjects. No evidence of allelic association was detected in either familial or sporadic PD, and linkage analysis excluded the TH locus, or a closely linked gene, as a major determinant of familial PD.
Url:
DOI: 10.1002/mds.870090312
Affiliations:
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Planté-Bordeneuve</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Neurogenetics and Movement Disorders Sections, University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Davis, M B" sort="Davis, M B" uniqKey="Davis M" first="M. B." last="Davis">M. B. Davis</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Neurogenetics and Movement Disorders Sections, University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Maraganore, D M" sort="Maraganore, D M" uniqKey="Maraganore D" first="D. M." last="Maraganore">D. M. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1994">1994</date><biblScope unit="vol">9</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="337">337</biblScope><biblScope unit="page" to="339">339</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">812A51DD79E4C5067DCE8912ECD748232F3959D3</idno><idno type="DOI">10.1002/mds.870090312</idno><idno type="ArticleID">MDS870090312</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Chromosome Mapping</term><term>DNA (genetics)</term><term>Gene Frequency (genetics)</term><term>Genetic Linkage (genetics)</term><term>Heterozygote Detection</term><term>Humans</term><term>Linkage analysis</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (enzymology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson's disease</term><term>Polymerase Chain Reaction</term><term>Polymorphism, Genetic</term><term>Tyrosine 3-Monooxygenase (blood)</term><term>Tyrosine 3-Monooxygenase (genetics)</term><term>Tyrosine hydroxylase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Frequency</term><term>Genetic Linkage</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Chromosome Mapping</term><term>Heterozygote Detection</term><term>Humans</term><term>Polymerase Chain Reaction</term><term>Polymorphism, Genetic</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tyrosine hydroxylase (TH) is a theoretical candidate gene determining susceptibility to Parkinson's disease (PD), and an association between one allele of a polymorphism at the TH locus and sporadic PD has been reported. We investigated TH polymorphism in 44 patients with sporadic PD, 48 patients with familial PD and 89 of their unaffected relatives, and 50 control subjects. No evidence of allelic association was detected in either familial or sporadic PD, and linkage analysis excluded the TH locus, or a closely linked gene, as a major determinant of familial PD.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Plante Ordeneuve, V" sort="Plante Ordeneuve, V" uniqKey="Plante Ordeneuve V" first="V." last="Planté-Bordeneuve">V. Planté-Bordeneuve</name></region><name sortKey="Davis, M B" sort="Davis, M B" uniqKey="Davis M" first="M. B." last="Davis">M. B. Davis</name><name sortKey="Harding" sort="Harding" uniqKey="Harding" last="Harding">Harding</name><name sortKey="Maraganore, D M" sort="Maraganore, D M" uniqKey="Maraganore D" first="D. M." last="Maraganore">D. M. Maraganore</name><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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